[Zinc-fans] advice on search for analogues

[Wang Tianhua]

Hi,
i have some hits and want to find commercially available similar compounds for testing. 
Seems there are two strategies I can use, one is to convert these structures into SMILES files and search using the web-based interface ZINC provides. The other choice is to download the structures of the compounds from ZINC and use some internal searching application I have on my own PC. Which way do you think makes more sense. 

Regards,
Tianhua